Which two tests are classified as non-treponemal tests?

Non-treponemal tests are serological tests used primarily for screening syphilis. The two tests that fall under this classification are the Rapid Plasma Reagin (RPR) test and the Venereal Disease Research Laboratory (VDRL) test.

These tests detect non-specific antibodies that are produced in response to tissue damage caused by the Treponema pallidum bacterium, which is responsible for syphilis. Both the RPR and VDRL tests are useful for initial screening because they are relatively quick, easy to perform, and can provide results that reflect recent infections. A positive result typically necessitates follow-up with treponemal tests, which are more specific and confirmatory, such as the FTA-ABS and MHA-TP tests.

In contrast, other tests mentioned, such as the FTA-ABS and MHA-TP, are classified as treponemal tests because they specifically detect antibodies that target the Treponema pallidum bacterium. Additionally, the ELISA and Western Blot tests are used for various applications, including the detection of specific antibodies to pathogens, not specifically focused on syphilis screening. Lastly, immunofluorescence and the Coombs test are also